Hydrochloric Acid → HCID 21190255, compound

HRID 619476Notes

Reaction equation

HRID 619476 reaction equation
[F:1][C:2]([F:24])([F:23])[C:3]([NH:5][CH2:6][CH2:7][CH2:8][CH2:9][N:10]1[CH2:20][C:19]2[N:21]3[C:12](=[CH:13][N:14]=[C:15]3[CH:16]=[CH:17][CH:18]=2)[C:11]1=[O:22])=[O:4].[ClH:25]>C(O)C>[ClH:25].[F:23][C:2]([F:1])([F:24])[C:3]([NH:5][CH2:6][CH2:7][CH2:8][CH2:9][N:10]1[CH2:20][C:19]2[N:21]3[C:12](=[CH:13][N:14]=[C:15]3[CH:16]=[CH:17][CH:18]=2)[C:11]1=[O:22])=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21190242HCID 21190242, compound

Product 1

HCID 21190255HCID 21190255, compoundYield 44.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 1.13 g (3.32 mmol) of 4,5-dihydro-4-(4-trifluoroacetamidobutan-1-yl)-3H-1,4,8b-triazaacenaphthylen-3-one in 20 ml of ethanol was added 0.42 ml (4.98 mmol) of 12N hydrochloric acid. The mixture was concentrated under reduced pressure. The resulting crystals was collected by filtration, which was washed with a small volume of ethanol and ether to afford 560 mg of the desired compound (44.8%, a white crystals.

Workup

  1. concentrationThe mixture was concentrated under reduced pressure
  2. filtrationThe resulting crystals was collected by filtration, which
  3. washwas washed with a small volume of ethanol and ether

Sources & evidence

ORD record
ord-6045bc6387a7460aab8eabc1b288097b
Source dataset
uspto-grants-1999_09
Patent number
US05958942

Reaction notes

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