Hydrochloric Acid → 4,5-Dihydro-4-(4-pentafluoropropion amidobutan-1-yl)-3h-1,4,8b-triazaacenaphthylene.dihydrochloride

HRID 619479Notes

Reaction equation

HRID 619479 reaction equation
[F:1][C:2]([F:26])([C:22]([F:25])([F:24])[F:23])[C:3]([NH:5][CH2:6][CH2:7][CH2:8][CH2:9][N:10]1[CH2:20][C:19]2[N:21]3[C:12](=[CH:13][N:14]=[C:15]3[CH:16]=[CH:17][CH:18]=2)[CH2:11]1)=[O:4].[ClH:27]>C(O)C>[ClH:27].[ClH:27].[F:26][C:2]([F:1])([C:22]([F:23])([F:24])[F:25])[C:3]([NH:5][CH2:6][CH2:7][CH2:8][CH2:9][N:10]1[CH2:20][C:19]2[N:21]3[C:12](=[CH:13][N:14]=[C:15]3[CH:16]=[CH:17][CH:18]=2)[CH2:11]1)=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 211901694,5-Dihydro-4-(4-pentafluoropropionamidobutan-1-yl)-3H-1,4,8b-triazaacenaphthylene

Product 1

HCID 211902144,5-Dihydro-4-(4-pentafluoropropion amidobutan-1-yl)-3h-1,4,8b-triazaacenaphthylene.dihydrochlorideYield 79.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 2230 mg (5.93 mmol) of 4,5-dihydro-4-(4-pentafluoropropionamidobutan-1-yl)-3H-1,4,8b-triazaacenaphthylene in 35 ml of ethanol was added 1.22 ml (14.31 mmol) of 12N hydrochloric acid. The mixture was stirred for one hour at room temperature. The resulting precipitates was collected by filtration, washed with a small volume of ethanol and ether, and dried to afford 2120 mg of the desired compound (76.9%, white crystals).

Workup

  1. customThe resulting precipitates
  2. filtrationwas collected by filtration
  3. washwashed with a small volume of ethanol and ether
  4. customdried

Sources & evidence

ORD record
ord-ae5930507d4848a48e0349b60e3195ed
Source dataset
uspto-grants-1999_09
Patent number
US05958942

Reaction notes

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