Hydrochloric Acid → HCID 21190202, compound

HRID 619485Notes

Reaction equation

HRID 619485 reaction equation
[F:1][C:2]([F:23])([F:22])[S:3]([NH:6][CH2:7][CH2:8][CH2:9][N:10]1[CH2:20][C:19]2[N:21]3[C:12](=[CH:13][N:14]=[C:15]3[CH:16]=[CH:17][CH:18]=2)[CH2:11]1)(=[O:5])=[O:4].[ClH:24]>C(O)C>[ClH:24].[ClH:24].[F:22][C:2]([F:1])([F:23])[S:3]([NH:6][CH2:7][CH2:8][CH2:9][N:10]1[CH2:20][C:19]2[N:21]3[C:12](=[CH:13][N:14]=[C:15]3[CH:16]=[CH:17][CH:18]=2)[CH2:11]1)(=[O:4])=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21190141HCID 21190141, compound

Product 1

HCID 21190202HCID 21190202, compoundYield 83.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 248 mg (0.72 mmol) of 4,5-dihydro-4-(3-trifluoromethanesulfonamidopropan-1-yl)-3H-1,4,8b-triazaacenaphthylene in 5.0 ml of ethanol was added 0.18 ml (2.16 mmol) of 12N HCl. The mixture was stirred, and concentrated under reduced pressure. resulting precipitates were washed with a small volume of ethanol and ether to afford 253 mg of the desired compound (84.2%, a white solid).

Workup

  1. concentrationconcentrated under reduced pressure
  2. customresulting
  3. customprecipitates
  4. washwere washed with a small volume of ethanol and ether

Sources & evidence

ORD record
ord-57f62b4cf3c14cf1832d4f7f40065e76
Source dataset
uspto-grants-1999_09
Patent number
US05958942

Reaction notes

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