Hydrochloric Acid → HCID 21190216, compound

HRID 619488Notes

Reaction equation

HRID 619488 reaction equation
[F:1][C:2]([F:29])([F:28])[S:3]([NH:6][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:25][C:24]3[N:26]4[C:17](=[CH:18][N:19]=[C:20]4[CH:21]=[CH:22][CH:23]=3)[C:16]2=[O:27])=[CH:11][CH:10]=1)(=[O:5])=[O:4].[ClH:30]>C(O)C>[ClH:30].[F:28][C:2]([F:1])([F:29])[S:3]([NH:6][CH2:7][CH2:8][C:9]1[CH:10]=[CH:11][C:12]([N:15]2[CH2:25][C:24]3[N:26]4[C:17](=[CH:18][N:19]=[C:20]4[CH:21]=[CH:22][CH:23]=3)[C:16]2=[O:27])=[CH:13][CH:14]=1)(=[O:4])=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21190065HCID 21190065, compound

Product 1

HCID 21190216HCID 21190216, compoundYield 69.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 85 mg (0.2 mmol) of 4,5-dihydro-4- [4-(2-trifluoromethanesulfonamidoethan-1-yl)phenyl]-3H-1,4,8b-triazaacenaphthylen-3-one in 5.0 ml of ethanol was added 0.04 ml (0.5 mmol) of 12N HCl. The mixture was stirred at room temperature, and concentrated under reduced pressure. The resulting precipitates were collected by filtration, and washed with a small volume of ethanol and ether to afford 64 mg of the desired compound (69.4%, a pale yellow solid).

Workup

  1. concentrationconcentrated under reduced pressure
  2. customThe resulting precipitates
  3. filtrationwere collected by filtration
  4. washwashed with a small volume of ethanol and ether

Sources & evidence

ORD record
ord-c43da4b7c70843e89ee5dab59e1aea6b
Source dataset
uspto-grants-1999_09
Patent number
US05958942

Reaction notes

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