Diisopropylethylamine → HCID 21190076, compound

HRID 619516Notes

Reaction equation

HRID 619516 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH2:7])=[CH:4][CH:3]=1.C(N(CC)C(C)C)(C)C.C([O:21][C:22]([C:24]1[N:29]2[C:30]([C:33](=[O:38])C(Cl)(Cl)Cl)=[CH:31][N:32]=[C:28]2[CH:27]=[CH:26][CH:25]=1)=O)C>C(#N)C>[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:7]2[C:22](=[O:21])[C:24]3[N:29]4[C:30](=[CH:31][N:32]=[C:28]4[CH:27]=[CH:26][CH:25]=3)[C:33]2=[O:38])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 4278144-AminobenzylamineHCID 15472383HCID 15472383, compound

Product 1

HCID 21190076HCID 21190076, compoundYield 88.5%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 1.47 g (12.0 mmol) of 4-aminobenzylamine and 1.68 g (13.0 mmol) of N,N-diisopropylethylamine was added a solution of 3.50 g (10.0 mmol) of 5-ethoxycarbonyl-3-trichloroacetylimidazo[1,2-a]pyridine in 10 ml of acetonitrile. The mixture was stirred for 7 hours at room temperature. The resulting precipitate was collected by filtration, washed with acetonitrile and dried to afford 2.586 g of the desired compound (86.7%, a yellow crystals).

Workup

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with acetonitrile
  3. customdried

Sources & evidence

ORD record
ord-db87ca38bd8c4c30aa2b4c2c15f764e5
Source dataset
uspto-grants-1999_09
Patent number
US05958942

Reaction notes

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