反应详情

温度

100 °C

A solution of 25 g of 1-(4-chlorophenyl)-2-pyridin-4-yl-ethanone in 285 ml of dioxan was treated with 20 g of selenium dioxide. The mixture was stirred at 100° C. for 1 hour and filtered. The solvent was evaporated and the residue was dissolved in dichloromethane. The solution was washed three times with water, dried over anhydrous magnesium sulphate and evaporated. The residue was dissolved in ethyl acetate, the solution was filtered over silica gel and evaporated to yield 23.7 g of 1-(4-chlorophenyl)-2-pyridin-4-yl-ethanedione, m.p. 119-120° C.

1. filtrationfiltered
2. customThe solvent was evaporated
3. dissolutionthe residue was dissolved in dichloromethane
4. washThe solution was washed three times with water
5. dry with materialdried over anhydrous magnesium sulphate
6. customevaporated
7. dissolutionThe residue was dissolved in ethyl acetate
8. filtrationthe solution was filtered over silica gel
9. customevaporated