HCID 57073292, compound → HCID 57026923, compound

HRID 619710Notes

Reaction equation

HRID 619710 reaction equation
C(OC([NH:11][C@H:12]1[C@H:15]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[NH:14][C:13]1=[O:23])=O)C1C=CC=CC=1.[H][H]>[Pd].C(OCC)(=O)C>[NH2:11][C@H:12]1[C@H:15]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[NH:14][C:13]1=[O:23]

Participants

5

Reactant 2

HCID 57073292HCID 57073292, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 57026923HCID 57026923, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

(3S, 4S)-3-benzyloxycarbonylamino-4-phenoxy-azetidin-2-one (63 mg, 0.2 mmole) is hydrogenated with 100 mg of 10% palladium on activated carbon in ethyl acetate (10 ml) at 50 psi hydrogen pressure at room temperature for 2 hours. After removal of catalyst by filtration, deprotected (3S, 4S)-3-amino-4-phenoxy-azetidin-2-one in ethyl acetate is obtained.

Workup

  1. customAfter removal of catalyst
  2. filtrationby filtration

Sources & evidence

ORD record
ord-00c52a41839e41a49bde5fac1afecf74
Source dataset
uspto-grants-1999_09
Patent number
US05959123

Reaction notes

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