Sodium Sulfite → HCID 23707901, compound

HRID 619715Notes

Reaction equation

HRID 619715 reaction equation
[CH:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([S:11](Cl)(=[O:13])=[O:12])[C:5]=2[CH:4]=[CH:3][N:2]=1.S([O-])([O-])=O.[Na+:19].[Na+]>O>[CH:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([S:11]([O-:13])=[O:12])[C:5]=2[CH:4]=[CH:3][N:2]=1.[Na+:19]

Participants

4

Reactant 2

HCID 24437Sodium SulfiteHCID 33716555-Isoquinolinesulfonyl chloride

Product 1

HCID 23707901HCID 23707901, compoundYield 25%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

After a mixture of 5-isoquinolinesulfonyl chloride 1.58 g (7.0 mmol), sodium sulfite 880 mg (7.0 mmol) and water 10 ml was heated and refluxed for 1 hour, the reaction mixture was concentrated under reduced pressure. Ethanol was added to the resulting residue to filter off insoluble materials, and the filtrate was concentrated under reduced pressure to give sodium 5-isoquinolinesulfinate 375 mg (25.0%).

Workup

  1. temperaturewas heated
  2. temperaturerefluxed for 1 hour
  3. concentrationthe reaction mixture was concentrated under reduced pressure
  4. additionEthanol was added to the resulting residue
  5. filtrationto filter off insoluble materials
  6. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-651af751772c45048ddf0e5608eb79cb
Source dataset
uspto-grants-1999_09
Patent number
US05959107

Reaction notes

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