Sulfuric Acid → HCID 15435688, compound

HRID 619721Notes

Reaction equation

HRID 619721 reaction equation
[CH:1]1[C:10]2[C:5](=[C:6]([S:11][C:12]3[CH:13]=[CH:14][C:15]([N+:19]([O-:21])=[O:20])=[C:16]([CH:18]=3)[NH2:17])[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1.S(=O)(=O)(O)[OH:23].OOS([O-])=O.[K+].[OH-:33].[Na+]>O>[CH:1]1[C:10]2[C:5](=[C:6]([S:11]([C:12]3[CH:13]=[CH:14][C:15]([N+:19]([O-:21])=[O:20])=[C:16]([CH:18]=3)[NH2:17])(=[O:23])=[O:33])[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1

Participants

6

Reactant 4

HCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 21846955HCID 21846955, compoundHCID 23707502Potassium hydroxy sulfite

Product 1

HCID 15435688HCID 15435688, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

According to the method in (b) method of Example 2, a mixture of 5-(5-isoquinolylsulfanyl)-2-nitroaniline 5.00 g (16.8 mmol), concentrated sulfuric acid 50 ml and OXONE (trademark) 20.70 g (33.7 mmol) was stirred at room temperature for 30 minutes. Water was added to the reaction mixture, the solution was neutralized with an aqueous 4N sodium hydroxide solution, the precipitates were collected and washed with water then with ether to give 5-(5-isoquinolylsulfonyl)-2-nitroaniline 5.54 g (quantitative).

Workup

  1. customthe precipitates were collected
  2. washwashed with water

Sources & evidence

ORD record
ord-1d9ee4f158d041b595d4c7d6e682c376
Source dataset
uspto-grants-1999_09
Patent number
US05959107

Reaction notes

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