Sulfuric Acid → HCID 15435688, compound

Participants

Reaction Steps

According to the method in (b) method of Example 2, a mixture of 5-(5-isoquinolylsulfanyl)-2-nitroaniline 5.00 g (16.8 mmol), concentrated sulfuric acid 50 ml and OXONE (trademark) 20.70 g (33.7 mmol) was stirred at room temperature for 30 minutes. Water was added to the reaction mixture, the solution was neutralized with an aqueous 4N sodium hydroxide solution, the precipitates were collected and washed with water then with ether to give 5-(5-isoquinolylsulfonyl)-2-nitroaniline 5.54 g (quantitative).

Provenance & Evidence