反应详情

To a solution of 10-methyl-9-oxo-9,10-dihydroacridine-2,7-disulfonyl dichloride from Example 7 (810 mg, 2 mmole) in THF (20 mL) was added 3,5-dimethylpiperidine (2 mL, 15 mmole) and the reaction mixture was stirred at room temperature for 6 hours. Solvent was evaporated and the residue was treated with 1 N HCl (50 mL) and stirred for 10 minutes. Yellow product was collected by filtration, washed with water and methanol and dried. Crude material was crystallized from chloroform-ethanol to provide 900 mg (80%) of yellow 11-4. MS 560 (MH+).

1. customSolvent was evaporated
2. additionthe residue was treated with 1 N HCl (50 mL)
3. stirringstirred for 10 minutes
4. filtrationYellow product was collected by filtration
5. washwashed with water and methanol
6. customdried
7. customCrude material was crystallized from chloroform-ethanol
8. customto provide 900 mg (80%) of yellow 11-4