(E)-2-phenylethene-1-sulfonyl chloride → HCID 53737535, compound

HRID 619790Notes

Reaction equation

HRID 619790 reaction equation
Cl.[NH2:2][C@H:3]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[C:12]#[N:13])[C:4]1=[O:17].[CH:18](/[S:26](Cl)(=[O:28])=[O:27])=[CH:19]\[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[C:12]([C:11]1[CH:10]=[C:9]([CH:16]=[CH:15][CH:14]=1)[CH2:8][N:5]1[CH2:6][CH2:7][C@H:3]([NH:2][S:26]([CH:18]=[CH:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)(=[O:28])=[O:27])[C:4]1=[O:17])#[N:13]

Participants

3

Reactant 2

HCID 5369377(E)-2-phenylethene-1-sulfonyl chlorideHCID 228707863-(3-(S)-Amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride

Product 1

HCID 53737535HCID 53737535, compound

Procedure

The title compound is prepared from 3-(3-(S)-amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride as in EXAMPLE 24, Part B using trans-b-styrenesulfonyl chloride in place of 6-methoxynaphthalene-2-sulfonyl chloride. The crude product is triturated from 50% EtOAc/hexanes to give the title compound as a solid.

Workup

  1. customThe crude product is triturated from 50% EtOAc/hexanes

Sources & evidence

ORD record
ord-e00e6d64aeb64fa08fbda3f650e43550
Source dataset
uspto-grants-1999_09
Patent number
US05958918

Reaction notes

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