HCID 10636676, compound → N-[(3S)-1-[(3-Cyanophenyl)methyl]-2-oxo-3-pyrrolidinyl]-2′-methoxy[1,1′-biphenyl]-4-sulfonamide

HRID 619793Notes

Reaction equation

HRID 619793 reaction equation
Cl.[NH2:2][C@H:3]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[C:12]#[N:13])[C:4]1=[O:17].[CH3:18][O:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[C:26]1[CH:31]=[CH:30][C:29]([S:32](Cl)(=[O:34])=[O:33])=[CH:28][CH:27]=1>>[C:12]([C:11]1[CH:10]=[C:9]([CH:16]=[CH:15][CH:14]=1)[CH2:8][N:5]1[CH2:6][CH2:7][C@H:3]([NH:2][S:32]([C:29]2[CH:28]=[CH:27][C:26]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=3[O:19][CH3:18])=[CH:31][CH:30]=2)(=[O:34])=[O:33])[C:4]1=[O:17])#[N:13]

Participants

3

Reactant 2

HCID 10636676HCID 10636676, compoundHCID 228707863-(3-(S)-Amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride

Product 1

HCID 10813876N-[(3S)-1-[(3-Cyanophenyl)methyl]-2-oxo-3-pyrrolidinyl]-2′-methoxy[1,1′-biphenyl]-4-sulfonamide

Procedure

The title compound is prepared from 3-(3-(S)-amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride as in EXAMPLE 24, Part B using 2'-methoxybiphenyl-4-sulfonyl chloride in place of 6-methoxynaphthalene-2-sulfonyl chloride. The crude product is purified by column chromatography eluting with a gradient of 10% EtOAc/CH2Cl2 to 20% EtOAc/CH2Cl2 to give the title compound as a white foam.

Workup

  1. customThe crude product is purified by column chromatography
  2. washeluting with a gradient of 10% EtOAc/CH2Cl2 to 20% EtOAc/CH2Cl2

Sources & evidence

ORD record
ord-13510f806b564e7d8a890a9b8a30bca0
Source dataset
uspto-grants-1999_09
Patent number
US05958918

Reaction notes

Loading…