HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 10636676, compound → N-[(3S)-1-[(3-Cyanophenyl)methyl]-2-oxo-3-pyrrolidinyl]-2′-methoxy[1,1′-biphenyl]-4-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 10636676 | HCID 10636676 | — |
| Reactant | 3-(3-(S)-Amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride | HCID 22870786 | — |
| Product | N-[(3S)-1-[(3-Cyanophenyl)methyl]-2-oxo-3-pyrrolidinyl]-2′-methoxy[1,1′-biphenyl]-4-sulfonamide | HCID 10813876 | — |
Reaction Steps
The title compound is prepared from 3-(3-(S)-amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride as in EXAMPLE 24, Part B using 2'-methoxybiphenyl-4-sulfonyl chloride in place of 6-methoxynaphthalene-2-sulfonyl chloride. The crude product is purified by column chromatography eluting with a gradient of 10% EtOAc/CH2Cl2 to 20% EtOAc/CH2Cl2 to give the title compound as a white foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05958918 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-13510f806b564e7d8a890a9b8a30bca0 |
| Source note | uspto-grants-1999_09 |