Triethylamine → HCID 56993570, compound

HRID 619796Notes

Reaction equation

HRID 619796 reaction equation
Cl.[NH2:2][C@H:3]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[C:12]#[N:13])[C:4]1=[O:17].C(N(CC)CC)C.S(O)(O)(=O)=O.[NH2:30][C:31]1[N:40]=[C:39]([NH2:41])[C:38]2[C:33](=[CH:34][CH:35]=[C:36]([S:42](Cl)(=[O:44])=[O:43])[CH:37]=2)[N:32]=1>O>[C:12]([C:11]1[CH:10]=[C:9]([CH:16]=[CH:15][CH:14]=1)[CH2:8][N:5]1[CH2:6][CH2:7][C@H:3]([NH:2][S:42]([C:36]2[CH:37]=[C:38]3[C:33](=[CH:34][CH:35]=2)[N:32]=[C:31]([NH2:30])[N:40]=[C:39]3[NH2:41])(=[O:43])=[O:44])[C:4]1=[O:17])#[N:13]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 13413784HCID 13413784, compoundHCID 228707863-(3-(S)-Amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride

Product 1

HCID 56993570HCID 56993570, compoundYield 25%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 3-(3-(S)-amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride (0.50 g, 2 mmol) in 8 mL of H2O is added triethyl amine (0.7 g, 7 mmol). After stirring for 10 minutes, 2,4-diamino-quinazoline-6-sulfonyl chloride sulfate salt (0.71 g, 2 mmol) is added. The solution is refluxed for 1 hour. After this time, the solution is cooled to ambient temperatures. The solution is filtered. The collected solid is dried under vacuum to give the title compound (0.22 g, 0.5 mmol) as a white solid.

Workup

  1. temperatureThe solution is refluxed for 1 hour
  2. temperatureAfter this time, the solution is cooled to ambient temperatures
  3. filtrationThe solution is filtered
  4. customThe collected solid is dried under vacuum

Sources & evidence

ORD record
ord-95102f677dae483883319a6dfdf95196
Source dataset
uspto-grants-1999_09
Patent number
US05958918

Reaction notes

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