Benzyl iodide → HCID 67365974, compound

HRID 619803Notes

Reaction equation

HRID 619803 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH:24]=[CH:25][CH:26]=1)[CH2:6][N:7]1[CH2:11][CH2:10][C@H:9]([NH:12][S:13]([C:16]2[S:17][C:18]([Cl:22])=[C:19]([Cl:21])[CH:20]=2)(=[O:15])=[O:14])[C:8]1=[O:23])#[N:2].[CH2:27](I)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[C:1]([C:3]1[CH:4]=[C:5]([CH:24]=[CH:25][CH:26]=1)[CH2:6][N:7]1[CH2:11][CH2:10][C@H:9]([N:12]([CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[S:13]([C:16]2[S:17][C:18]([Cl:22])=[C:19]([Cl:21])[CH:20]=2)(=[O:14])=[O:15])[C:8]1=[O:23])#[N:2]

Participants

3

Reactant 2

HCID 12098Benzyl iodideHCID 54497438HCID 54497438, compound

Product 1

HCID 67365974HCID 67365974, compound

Procedure

The title compound is prepared as described in EXAMPLE 25, Part A using 4,5-dichlorothiophene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide, prepared as described in EXAMPLE 80, part A, and benzyl iodide. The crude product is purified by column chromatography eluting with gradient of 20% EtOAc/hexanes to 40% EtOAc/hexanes to afford the title compound as a white foam.

Workup

  1. customThe title compound is prepared
  2. customprepared
  3. customThe crude product is purified by column chromatography
  4. washeluting with gradient of 20% EtOAc/hexanes to 40% EtOAc/hexanes

Sources & evidence

ORD record
ord-ed917609fba549329c709304745b3410
Source dataset
uspto-grants-1999_09
Patent number
US05958918

Reaction notes

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