HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-methoxynaphthalene-2-sulfonyl Chloride → HCID 67365870, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-methoxynaphthalene-2-sulfonyl Chloride | HCID 10515266 | — |
| Reactant | 3-(3-(S)-Amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride | HCID 22870786 | — |
| Product | HCID 67365870 | HCID 67365870 | — |
Reaction Steps
The title compound is prepared as in EXAMPLE 24, Part B substituting 3-(3-(S)-Amino-2-oxo-azetidin-1-ylmethyl)benzonitrile hydrochloride for 3-(3-(S)-amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride and using 7-methoxynaphthalene-2-sulfonyl chloride in place of 6-methoxynaphthalene-2-sulfonyl chloride. The crude product is purified by column chromatography eluting with a gradient of 20% EtOAc/CH2Cl2 to 30% EtOAc/CH2Cl2 to give the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05958918 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-9c9ac7ae67024c4f9c545d2ce86e111d |
| Source note | uspto-grants-1999_09 |