Benzyl Bromide → HCID 53809035, compound

HRID 619807Notes

Reaction equation

HRID 619807 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH:28]=[CH:29][CH:30]=1)[CH2:6][N:7]1[CH2:10][C@H:9]([NH:11][S:12]([C:15]2[CH:24]=[CH:23][C:22]3[C:17](=[CH:18][C:19]([O:25][CH3:26])=[CH:20][CH:21]=3)[CH:16]=2)(=[O:14])=[O:13])[C:8]1=[O:27])#[N:2].[CH2:31](Br)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[C:1]([C:3]1[CH:4]=[C:5]([CH:28]=[CH:29][CH:30]=1)[CH2:6][N:7]1[CH2:10][C@H:9]([N:11]([CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[S:12]([C:15]2[CH:24]=[CH:23][C:22]3[C:17](=[CH:18][C:19]([O:25][CH3:26])=[CH:20][CH:21]=3)[CH:16]=2)(=[O:14])=[O:13])[C:8]1=[O:27])#[N:2]

Participants

3

Reactant 2

HCID 7498Benzyl BromideHCID 67365870HCID 67365870, compound

Product 1

HCID 53809035HCID 53809035, compound

Procedure

The title compound is prepared as described in EXAMPLE 25, Part A using 7-methoxynaphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxoazetidin-3-(S)-yl]amide, prepared as described in Example 65, part D, and benzyl bromide. The crude product is purified by column chromatography eluting with gradient of 30% EtOAc/hexanes to 40% EtOAc/hexanes to afford the title compound as a white foam.

Workup

  1. customThe title compound is prepared
  2. customprepared
  3. customThe crude product is purified by column chromatography
  4. washeluting with gradient of 30% EtOAc/hexanes to 40% EtOAc/hexanes

Sources & evidence

ORD record
ord-e08720cbe4484647961a89aedad9eae3
Source dataset
uspto-grants-1999_09
Patent number
US05958918

Reaction notes

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