HCID 10801111, compound → HCID 10646532, compound

HRID 619816Notes

Reaction equation

HRID 619816 reaction equation
Cl.[NH2:2][C@H:3]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[C:12]#[N:13])[C:4]1=[O:17].[CH3:18][N:19]1[CH:23]=[CH:22][N:21]=[C:20]1[C:24]1[CH:29]=[CH:28][C:27]([S:30](Cl)(=[O:32])=[O:31])=[CH:26][CH:25]=1>>[C:12]([C:11]1[CH:10]=[C:9]([CH:16]=[CH:15][CH:14]=1)[CH2:8][N:5]1[CH2:6][CH2:7][C@H:3]([NH:2][S:30]([C:27]2[CH:26]=[CH:25][C:24]([C:20]3[N:19]([CH3:18])[CH:23]=[CH:22][N:21]=3)=[CH:29][CH:28]=2)(=[O:31])=[O:32])[C:4]1=[O:17])#[N:13]

Participants

3

Reactant 2

HCID 10801111HCID 10801111, compoundHCID 228707863-(3-(S)-Amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride

Product 1

HCID 10646532HCID 10646532, compound

Procedure

The title compound is prepared from 3-(3-(S)-amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride as in EXAMPLE 24, Part B using (1-methyl-1H-imidazol-2-yl)benzene-4-sulfonyl chloride in place of 6-methoxynaphthalene-2-sulfonyl chloride. The crude product is purified by column chromatography eluting with 5% MeOH/CH2Cl2 to give the title compound as a white foam.

Workup

  1. customThe crude product is purified by column chromatography
  2. washeluting with 5% MeOH/CH2Cl2

Sources & evidence

ORD record
ord-1c4a2df589df465b9da03f6d10bf446b
Source dataset
uspto-grants-1999_09
Patent number
US05958918

Reaction notes

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