反应详情

4-Bromopyridine hydrochloride is free based with saturated NaHCO3 solution and extracted into methylene chloride. The organic solution is concentrated at room temperature and used immediately without further purification. A portion of the solid obtained (3 g, 19 mmol) is treated as described in EXAMPLE 53, Part A with n-butyl lithium (14.25 mL of a 1.6 M solution in TIF, 22.8 mmol) and iodobromobenzene (5.39 g, 19 mmol). The crude product is purified by chromatography (30% EtOAc/hexanes to 60% EtOAc/hexanes) to obtain the title compound (2.59 g, 11.06 mmol).

1. extractionextracted into methylene chloride
2. concentrationThe organic solution is concentrated at room temperature
3. customused immediately without further purification
4. customA portion of the solid obtained (3 g, 19 mmol)
5. additionis treated
6. customThe crude product is purified by chromatography (30% EtOAc/hexanes to 60% EtOAc/hexanes)