7-methoxynaphtalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide → HCID 10768584, compound

HRID 619821Notes

Reaction equation

HRID 619821 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH:29]=[CH:30][CH:31]=1)[CH2:6][N:7]1[CH2:11][CH2:10][C@H:9]([NH:12][S:13]([C:16]2[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][C:20]([O:26][CH3:27])=[CH:21][CH:22]=3)[CH:17]=2)(=[O:15])=[O:14])[C:8]1=[O:28])#[N:2].[S:32]1[CH:36]=[CH:35][CH:34]=[C:33]1[CH2:37]Br>>[C:1]([C:3]1[CH:4]=[C:5]([CH:29]=[CH:30][CH:31]=1)[CH2:6][N:7]1[CH2:11][CH2:10][C@H:9]([N:12]([CH2:37][C:33]2[S:32][CH:36]=[CH:35][CH:34]=2)[S:13]([C:16]2[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][C:20]([O:26][CH3:27])=[CH:21][CH:22]=3)[CH:17]=2)(=[O:15])=[O:14])[C:8]1=[O:28])#[N:2]

Participants

3

Reactant 2

HCID 105508547-methoxynaphtalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amideHCID 118299782-(Bromomethyl)thiophene

Product 1

HCID 10768584HCID 10768584, compound

Procedure

The title compound is prepared as described in EXAMPLE 90, Part A using 7-methoxynaphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide (0.100 g, 0.23 mmol), prepared as described in EXAMPLE 43, part A, and thiophene-2-ylmethyl bromide (0.10 g, 0.56 mmol). The crude product is triturated with hexane/ether and used without further purification.

Workup

  1. customprepared
  2. customThe crude product is triturated with hexane/ether
  3. customused without further purification

Sources & evidence

ORD record
ord-aa32c85161f1452e8c0c415f7a6c5327
Source dataset
uspto-grants-1999_09
Patent number
US05958918

Reaction notes

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