HCID 10682327, compound → HCID 10526725, compound

HRID 619823Notes

Reaction equation

HRID 619823 reaction equation
Cl.[NH2:2][C@H:3]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[C:12]#[N:13])[C:4]1=[O:17].[N:18]1[CH:23]=[CH:22][CH:21]=[C:20]([C:24]2[CH:29]=[CH:28][C:27]([S:30](Cl)(=[O:32])=[O:31])=[CH:26][CH:25]=2)[CH:19]=1>>[C:12]([C:11]1[CH:10]=[C:9]([CH:16]=[CH:15][CH:14]=1)[CH2:8][N:5]1[CH2:6][CH2:7][C@H:3]([NH:2][S:30]([C:27]2[CH:26]=[CH:25][C:24]([C:20]3[CH:19]=[N:18][CH:23]=[CH:22][CH:21]=3)=[CH:29][CH:28]=2)(=[O:31])=[O:32])[C:4]1=[O:17])#[N:13]

Participants

3

Reactant 2

HCID 10682327HCID 10682327, compoundHCID 228707863-(3-(S)-Amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride

Product 1

HCID 10526725HCID 10526725, compound

Procedure

The title compound is prepared from 3-(3-(S)-amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride (0.3 g, 1.2 mmol) as in EXAMPLE 24, Part B using 4-pyridin-3-ylbenzenesulfonyl chloride (0.57 g, 2.4 mmol) in place of 6-methoxynaphthalene-2-sulfonyl chloride. The crude product is purified by chromatography (2.5% MeOH/CH2Cl2 to 5% MeOH/CH2Cl2) to obtain a white solid (0.08 g, 0.18 mmol).

Workup

  1. customThe crude product is purified by chromatography (2.5% MeOH/CH2Cl2 to 5% MeOH/CH2Cl2)

Sources & evidence

ORD record
ord-33a5a74736ef406f90e7dc3d66746eb3
Source dataset
uspto-grants-1999_09
Patent number
US05958918

Reaction notes

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