Dichloromethane → HCID 54176525, compound

HRID 619824Notes

Reaction equation

HRID 619824 reaction equation
Cl.[NH2:2][C@H:3]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[C:12]#[N:13])[C:4]1=[O:17].[CH3:18][O:19][C:20]1[CH:29]=[CH:28][C:27]2[C:22](=[CH:23][C:24]([S:30](Cl)(=[O:32])=[O:31])=[CH:25][CH:26]=2)[N:21]=1.C(Cl)Cl>CO.C(Cl)Cl>[C:12]([C:11]1[CH:10]=[C:9]([CH:16]=[CH:15][CH:14]=1)[CH2:8][N:5]1[CH2:6][CH2:7][C@H:3]([NH:2][S:30]([C:24]2[CH:23]=[C:22]3[C:27]([CH:28]=[CH:29][C:20]([O:19][CH3:18])=[N:21]3)=[CH:26][CH:25]=2)(=[O:31])=[O:32])[C:4]1=[O:17])#[N:13]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 21845933HCID 21845933, compoundHCID 228707863-(3-(S)-Amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride

Product 1

HCID 54176525HCID 54176525, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is prepared from 3-(3-(S)-amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride (0.305, 1.2 mmol) as in EXAMPLE 24, Part B using 2-methoxyquinoline-7-sulfonyl chloride (0.30 g, 1.16 mmol) in place of 6-methoxynaphthalene-2-sulfonyl chloride. 2-Methoxy-quinoline-7-sulfonic acid {1-[3-cyanobenzyl]-2-oxopyrrolidin-3-(S)-yl}amide is obtained as a solid (0.27 g, 0.62 mmol) upon chromatography (CH2Cl2 to 3% MeOH/CH2Cl2).

Sources & evidence

ORD record
ord-96213e7507ae432b99f8e66e83f873e1
Source dataset
uspto-grants-1999_09
Patent number
US05958918

Reaction notes

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