HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 54176525, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | HCID 21845933 | HCID 21845933 | — |
| Reactant | 3-(3-(S)-Amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride | HCID 22870786 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 54176525 | HCID 54176525 | — |
Reaction Steps
The title compound is prepared from 3-(3-(S)-amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride (0.305, 1.2 mmol) as in EXAMPLE 24, Part B using 2-methoxyquinoline-7-sulfonyl chloride (0.30 g, 1.16 mmol) in place of 6-methoxynaphthalene-2-sulfonyl chloride. 2-Methoxy-quinoline-7-sulfonic acid {1-[3-cyanobenzyl]-2-oxopyrrolidin-3-(S)-yl}amide is obtained as a solid (0.27 g, 0.62 mmol) upon chromatography (CH2Cl2 to 3% MeOH/CH2Cl2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05958918 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-96213e7507ae432b99f8e66e83f873e1 |
| Source note | uspto-grants-1999_09 |