Trifluoroacetic acid → HCID 18392431, compound

HRID 619840Notes

Reaction equation

HRID 619840 reaction equation
C([O:5][C:6](=[O:38])[CH2:7][N:8]([C@H:24]1[CH2:28][CH2:27][N:26]([CH2:29][C:30]2[CH:34]=[C:33]([C:35]#[N:36])[S:32][CH:31]=2)[C:25]1=[O:37])[S:9]([C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][C:16]([O:22][CH3:23])=[CH:17][CH:18]=2)[CH:13]=1)(=[O:11])=[O:10])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:35]([C:33]1[S:32][CH:31]=[C:30]([CH2:29][N:26]2[CH2:27][CH2:28][C@H:24]([N:8]([S:9]([C:12]3[CH:21]=[CH:20][C:19]4[C:14](=[CH:15][C:16]([O:22][CH3:23])=[CH:17][CH:18]=4)[CH:13]=3)(=[O:11])=[O:10])[CH2:7][C:6]([OH:38])=[O:5])[C:25]2=[O:37])[CH:34]=1)#[N:36]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 54519209HCID 54519209, compound

Product 1

HCID 18392431HCID 18392431, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 2-[[1-(5-cyanothiophene-3-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]-(7-methoxynaphthalene-2-sulfonyl)amino]acetic acid tert-butyl ester (0.40 g, 0.72 mmol) in 15 mL of CH2Cl2 is added 5 mL of TFA. After 2 hours, the solution is concentrated to give the title compound as a white foam.

Workup

  1. concentrationthe solution is concentrated

Sources & evidence

ORD record
ord-83ebdae0622145048e474d57dc125ae9
Source dataset
uspto-grants-1999_09
Patent number
US05958918

Reaction notes

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