Benzyl Bromide → HCID 18392444, compound

HRID 619843Notes

Reaction equation

[C:1]([C:3]1[S:7][CH:6]=[C:5]([CH2:8][N:9]2[CH2:13][CH2:12][C@H:11]([NH:14][S:15]([C:18]3[S:19][C:20]([Cl:24])=[C:21]([Cl:23])[CH:22]=3)(=[O:17])=[O:16])[C:10]2=[O:25])[CH:4]=1)#[N:2].[CH2:26](Br)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[C:1]([C:3]1[S:7][CH:6]=[C:5]([CH2:8][N:9]2[CH2:13][CH2:12][C@H:11]([N:14]([CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[S:15]([C:18]3[S:19][C:20]([Cl:24])=[C:21]([Cl:23])[CH:22]=3)(=[O:17])=[O:16])[C:10]2=[O:25])[CH:4]=1)#[N:2]

Participants

Reactant 2

HCID 7498Benzyl Bromide

HCID 53836486HCID 53836486, compound

Product 1

HCID 18392444HCID 18392444, compound

Procedure

The title compound is prepared as in EXAMPLE 126, Part A using 4,5-dichlorothiophene-2-sulfonic acid [1-(5-cyanothiophen-3-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]amide in place of 7-methoxynaphthalene-2-sulfonic acid [1-(5-cyanothiophen-3-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]amide and benzyl bromide in place of MeI to give the title compound as a white foam.

Workup

customThe title compound is prepared as in EXAMPLE 126, Part A

Sources & evidence

ORD record: ord-44bc6bf5a39a4eb6baad88f0cac1db90
Source dataset: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05958918

Reaction notes

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