Trifluoroacetic acid → HCID 18392427, compound

HRID 619844Notes

Reaction equation

HRID 619844 reaction equation
C([O:5][C:6](=[O:33])[CH2:7][N:8]([C@H:19]1[CH2:23][CH2:22][N:21]([CH2:24][C:25]2[CH:29]=[C:28]([C:30]#[N:31])[S:27][CH:26]=2)[C:20]1=[O:32])[S:9]([C:12]1[S:13][C:14]([Cl:18])=[C:15]([Cl:17])[CH:16]=1)(=[O:11])=[O:10])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:30]([C:28]1[S:27][CH:26]=[C:25]([CH2:24][N:21]2[CH2:22][CH2:23][C@H:19]([N:8]([S:9]([C:12]3[S:13][C:14]([Cl:18])=[C:15]([Cl:17])[CH:16]=3)(=[O:10])=[O:11])[CH2:7][C:6]([OH:33])=[O:5])[C:20]2=[O:32])[CH:29]=1)#[N:31]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 53678461HCID 53678461, compound

Product 1

HCID 18392427HCID 18392427, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 2-[[1-(5-cyanothiophene-3-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]-(4,5-dichlorothiophene-2-sulfonyl)amino]acetic acid tert-butyl ester (0.40 g, 0.72 mmol) in 15 mL of CH2Cl2 is added 5 mL of TFA. After 2 hours, the solution is concentrated to give the title compound as a white foam.

Workup

  1. concentrationthe solution is concentrated

Sources & evidence

ORD record
ord-cd679f06aeed450ba537c21b53549998
Source dataset
uspto-grants-1999_09
Patent number
US05958918

Reaction notes

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