Methyl iodide → HCID 57137766, compound

HRID 619853Notes

Reaction equation

HRID 619853 reaction equation
[C:1]([C:3]1[S:7][C:6]([CH2:8][N:9]2[CH2:13][CH2:12][C@H:11]([NH:14][S:15]([C:18]3[CH:27]=[CH:26][C:25]4[C:20](=[CH:21][C:22]([O:28][CH3:29])=[CH:23][CH:24]=4)[CH:19]=3)(=[O:17])=[O:16])[C:10]2=[O:30])=[CH:5][CH:4]=1)#[N:2].C(C1SC=C(CN2CC[C@H](NS([C:48]3[CH:57]=[CH:56][C:55]4[C:50](=[CH:51]C(OC)=CC=4)[CH:49]=3)(=O)=O)C2=O)C=1)#N.C(Br)C1C=CC=CC=1.CI>>[C:1]([C:3]1[S:7][C:6]([CH2:8][N:9]2[CH2:13][CH2:12][C@H:11]([N:14]([CH2:51][C:50]3[CH:55]=[CH:56][CH:57]=[CH:48][CH:49]=3)[S:15]([C:18]3[CH:27]=[CH:26][C:25]4[C:20](=[CH:21][C:22]([O:28][CH3:29])=[CH:23][CH:24]=4)[CH:19]=3)(=[O:17])=[O:16])[C:10]2=[O:30])=[CH:5][CH:4]=1)#[N:2]

Participants

5

Reactant 4

HCID 6328Methyl iodideHCID 7498Benzyl BromideHCID 105271317-methoxynaphthalene-2-sulfonic acid [1-(5-cyanothiophen-2-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]amideHCID 10670821HCID 10670821, compound

Product 1

HCID 57137766HCID 57137766, compound

Procedure

The title compound is prepared as in EXAMPLE 126, Part A using 7-methoxynaphthalene-2-sulfonic acid[1-(5-cyanothiophen-2-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]amide, prepared as in EXAMPLE 148, Part A, in place of 7-methoxynaphthalene-2-sulfonic acid [1-(5-cyanothiophen-3-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]amide and benzyl bromide for methyl iodide.

Sources & evidence

ORD record
ord-9dd09928ef1341388717164ebf2bb480
Source dataset
uspto-grants-1999_09
Patent number
US05958918

Reaction notes

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