HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-(3-(S)-Amino-2-oxopyrrolidin-1-ylmethyl)pyridine-2-carbonitrile trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | [1-(2-Cyano-pyridin-4-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]carbamic acid tert-butyl ester | HCID 10829192 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(3-(S)-Amino-2-oxopyrrolidin-1-ylmethyl)pyridine-2-carbonitrile trifluoroacetate | HCID 18392442 | — |
Reaction Steps
To a solution of [1-(2-cyano-pyridin-4-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]carbamic acid tert-butyl ester (3.34 g, 10.6 mmol) in 50 mL of CH2Cl2 is added 5 mL of TFA. The reaction mixture is stirred for 18 hours and then concentrated to give the title compound (3.40 g, 10.3 mmol) as a white foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05958918 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-5e3366afbc5245b29a1c4c08d12cb7d2 |
| Source note | uspto-grants-1999_09 |