HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon tetrabromide → 5-(Bromomethyl)furan-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon tetrabromide | HCID 11205 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 5-(Hydroxymethyl)furan-2-carbonitrile | HCID 3021406 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-(Bromomethyl)furan-2-carbonitrile | HCID 10821395 | 85.7% |
Reaction Steps
5-Hydoxymethylfuran-2-carbononitrile (1.12 g, 9.1 mmol) is dissolved in THF (75 mL), treated with triphenylphosphine (2.9 g, 11.06 mmol), carbon tetrabromide (3.78 g, 11.4 mmol) and stirred at room temperature for 18 hours. Standard workup yields the title compound (1.45 g, 7.8 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05958918 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-1cc42026e8f94da08317e6191a13eb07 |
| Source note | uspto-grants-1999_09 |