Carbamic acid, (2-propoxy-4-pyridinyl)-, 1,1-dimethylethyl ester → HCID 21247419, compound

HRID 619878Notes

Reaction equation

HRID 619878 reaction equation
[CH2:1]([O:4][C:5]1[CH:10]=[C:9]([NH:11]C(=O)OC(C)(C)C)[CH:8]=[CH:7][N:6]=1)[CH2:2][CH3:3]>FC(F)(F)C(O)=O>[NH2:11][C:9]1[CH:8]=[CH:7][N:6]=[C:5]([O:4][CH2:1][CH2:2][CH3:3])[CH:10]=1

Participants

3

Reactant 1

HCID 54325245Carbamic acid, (2-propoxy-4-pyridinyl)-, 1,1-dimethylethyl ester

Product 1

HCID 21247419HCID 21247419, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 4.4 grams (0.017 mole) of (1,1-dimethylethyl) N-(2-propoxy-4-pyridinyl)carbamate in 20 ml of trifluoroacetic acid was stirred at ambient temperature for one hour. The excess trifluoroacetic acid was removed under reduced pressure. The yield of 4-amino-2-propoxypyridine was 2.6 grams as an oil.

Workup

  1. customThe excess trifluoroacetic acid was removed under reduced pressure

Sources & evidence

ORD record
ord-09e24b0ca3764c1fa860eb3ec32b09f9
Source dataset
uspto-grants-1989_04
Patent number
US04818271

Reaction notes

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