Dabco → HCID 13852724, compound

HRID 619900Notes

Reaction equation

HRID 619900 reaction equation
[CH3:1][CH:2]([S:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[S:13]([N:16]=[C:17]=[O:18])(=[O:15])=[O:14])(=[O:6])=[O:5])[CH3:3].[NH2:19][C:20]1[N:25]=[C:24]([CH3:26])[CH:23]=[C:22]([CH3:27])[N:21]=1.C1N2CCN(CC2)C1>ClCCl>[CH3:27][C:22]1[CH:23]=[C:24]([CH3:26])[N:25]=[C:20]([NH:19][C:17]([NH:16][S:13]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[S:4]([CH:2]([CH3:1])[CH3:3])(=[O:6])=[O:5])(=[O:14])=[O:15])=[O:18])[N:21]=1

Participants

5

Reactant 3

HCID 9237DabcoHCID 130212-Amino-4,6-dimethyl pyrimidineHCID 13852723HCID 13852723, compound

Product 1

HCID 13852724HCID 13852724, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 2-[(1-methylethyl)sulfonyl]benzenesulfonyl isocyanate (2.3 g, 0.008 mol) in dichloromethane (12 ml) was added to 2-amino-4,6-dimethylpyrimidine (0.74 g, 0.006 mol) and DABCO (catalytic amount) and the suspension was stirred overnight at room temperature. The solvent was removed in vacuo and acetonitrile was added to the residue. The precipitated solid was filtered and dried to give N-[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-2-[(1-methylethyl)sulfonyl]benzenesulfonamide as a white powder, m.p. 188°-193° (dec.).

Workup

  1. customThe solvent was removed in vacuo and acetonitrile
  2. additionwas added to the residue
  3. filtrationThe precipitated solid was filtered
  4. customdried

Sources & evidence

ORD record
ord-7fadf50f2bdf47b78cbb3829b943e988
Source dataset
uspto-grants-1989_04
Patent number
US04818277

Reaction notes

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