Tetrafluoroboric acid → HCID 21247704, compound

HRID 619989Notes

Reaction equation

HRID 619989 reaction equation
N[C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[CH2:10][O:9]2)=[CH:4][CH:3]=1.N([O-])=O.[Na+].[F:23][B-](F)(F)F.[H+]>Cl.O>[F:23][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[CH2:10][O:9]2)=[CH:4][CH:3]=1

Participants

6

Reactant 3

HCID 28118Tetrafluoroboric acidHCID 21248029HCID 21248029, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 21247704HCID 21247704, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent2×

Procedure

24.7 g of 2-p-aminophenyl-5-pentyl-tetrahydropyran are dissolved in a mixture of 25 ml of concentrated hydrochloric acid and 75 ml of water, and diazotized at 3°-6° with a solution of 8 g of NaNO2 in 15 ml of water. Then 24 g of 40% tetrafluoroboric acid are added, and the precipitated diazonium tetrafluoroborate is filtered off, washed with water and dried. The diazonium salt is heated to about 150°, and the residue is worked up as usual. 2-p-Fluorophenyl-5-pentyl-tetrahydropyran is obtained.

Workup

  1. filtrationthe precipitated diazonium tetrafluoroborate is filtered off
  2. washwashed with water
  3. customdried
  4. temperatureThe diazonium salt is heated to about 150°

Sources & evidence

ORD record
ord-2a9105b547cd4f398da32b7c14fb2c43
Source dataset
uspto-grants-1989_04
Patent number
US04818431

Reaction notes

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