反应详情

Chloroacetyl chloride (64 g) is added to a stirred solution of 3,4-dihydrocarbostyril (40 g) and aluminum chloride (76 g) in methylene chloride (500 ml). The reaction mixture is refluxed for 3 hours, cooled to RT and poured into ice water affording a white solid which is filtered, washed with water, dried, and recrystallized from ethanol, yielding the desired product.

1. temperatureThe reaction mixture is refluxed for 3 hours
2. filtrationis filtered
3. washwashed with water
4. customdried
5. customrecrystallized from ethanol