참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Chloroacetic Acid | HCID 300 | — |
| 반응물 | N1-Benzylbenzene-1,2-diamine | HCID 2735482 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 1-Benzyl-2-chloromethyl-1H-benzoimidazole | HCID 563436 | 73.3% |
반응 단계
N-benzyl-o-phenylenediamine (3 g, 15 mmol), which is a known compound, was added to polyphosphoric ester (10 g), to which monochloroacetic acid (1.1 g, 12 mmol) was added and heated at 120° C. for 1 hour. Then water was added to the mixture to decompose remaining polyphosphoric ester. The resultant was refined in a conventional process and the title intermediate (2.25 g, 8.8 mmol) was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04818761 |
|---|
| 출처 데이터셋 | uspto-grants-1989_04 |
|---|
| ORD ID | ord-4078903d91a04b40948dd88102af506c |
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| 출처 메모 | uspto-grants-1989_04 |
|---|
