Chloroacetic Acid → 1-Benzyl-2-chloromethyl-1H-benzoimidazole

HRID 620029Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 620029
[CH2:1]([NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[NH2:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:16][CH2:17][C:18](O)=O>O>[CH2:1]([N:8]1[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[N:15]=[C:18]1[CH2:17][Cl:16])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 300Chloroacetic AcidHCID 2735482N1-Benzylbenzene-1,2-diamine

Produkt 1

HCID 5634361-Benzyl-2-chloromethyl-1H-benzoimidazoleAusbeute 73,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

N-benzyl-o-phenylenediamine (3 g, 15 mmol), which is a known compound, was added to polyphosphoric ester (10 g), to which monochloroacetic acid (1.1 g, 12 mmol) was added and heated at 120° C. for 1 hour. Then water was added to the mixture to decompose remaining polyphosphoric ester. The resultant was refined in a conventional process and the title intermediate (2.25 g, 8.8 mmol) was obtained.

Aufarbeitung

  1. additionwas added

Quellen und Nachweise

ORD-Eintrag
ord-4078903d91a04b40948dd88102af506c
Quelldatensatz
uspto-grants-1989_04
Patentnummer
US04818761

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