Diisopropyl Ether → HCID 19023492, compound

HRID 620054Notes

Reaction equation

HRID 620054 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[N:7]1[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH2:15][CH2:16][N:17]2[C:21](=[O:22])[C:20]3[CH:23]=[CH:24][C:25]([NH2:27])=[CH:26][C:19]=3[S:18]2(=[O:29])=[O:28])[CH2:9][CH2:8]1.[CH:30]([O:33]C(C)C)(C)[CH3:31]>C(OC(=O)C)(=O)C>[N:3]1[CH:4]=[CH:5][CH:6]=[N:1][C:2]=1[N:7]1[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH2:15][CH2:16][N:17]2[C:21](=[O:22])[C:20]3[CH:23]=[CH:24][C:25]([NH:27][C:30](=[O:33])[CH3:31])=[CH:26][C:19]=3[S:18]2(=[O:28])=[O:29])[CH2:9][CH2:8]1

Participants

4

Reactant 2

HCID 7914Diisopropyl EtherHCID 19023477HCID 19023477, compound

Product 1

HCID 19023492HCID 19023492, compound

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

200 ml of acetic anhydride are addedt o 0.06 mol of 2-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-6-amino-1,2-benzoisothiazol-3(2H)one 1,1-dioxide, and the mixture is stirred at room temperature for 12 hours. It is then evaporatd to dryness, isopropyl ether is added and the mixture is stirred for 1 hour. It is then filtered and the colourless crystals are dried in vacuo.

Workup

  1. additionis added
  2. stirringthe mixture is stirred for 1 hour
  3. filtrationIt is then filtered
  4. customthe colourless crystals are dried in vacuo

Sources & evidence

ORD record
ord-80bf1e30b9474f2f8dd60e2e777870ab
Source dataset
uspto-grants-1989_04
Patent number
US04818756

Reaction notes

Loading…