Water → HCID 19023428, compound

HRID 620056Notes

Reaction equation

Br[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[S:10](=[O:12])(=[O:11])[C:9]2[CH:13]=[CH:14][CH:15]=[CH:16][C:8]=2[S:7]1(=[O:18])=[O:17].[N:19]1[CH:24]=[CH:23][CH:22]=[N:21][C:20]=1[N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1.O>CN(C=O)C>[N:19]1[CH:24]=[CH:23][CH:22]=[N:21][C:20]=1[N:25]1[CH2:30][CH2:29][N:28]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]2[S:10](=[O:12])(=[O:11])[C:9]3[CH:13]=[CH:14][CH:15]=[CH:16][C:8]=3[S:7]2(=[O:18])=[O:17])[CH2:27][CH2:26]1

Participants

Conditions

Temperature: 0 °C

Procedure

0.028 mol of 2-(4-bromobutyl)-1,3,2-benzodithiazole 1,1,3,3-tetroxide and 0.056 mol of 1-(2-pyrimidinyl)piperazine in 125 ml of absolute DMF are stirred at 250° C. for 6 hours. The mixture is then cooled to 0° C., 150 ml of water are added dropwise with stirring, and the substance which has crystallised out is filtered off with suction. The product is purified by chromatography on silic gel; the eluting agent is ethyl acetate.

Workup

customthe substance which has crystallised out
filtrationis filtered off with suction
customThe product is purified by chromatography on silic gel

Sources & evidence

ORD record: ord-19f234df0a6a49f5aa36a9facd8bc4fb
Source dataset: uspto-grants-1989_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04818756

Reaction notes

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