反应详情

Anisole (32.4 g) and aluminium trichloride (36.0 g) are added to 1,2-dichloroethane (240 ml). The mixture is cooled to -5° and (3-trifluoromethylphenyl)-acetyl chloride (66.8 g) is slowly added. The mixture is stirred for 11/2 hours and poured into a mixture of crushed ice (400 g) and water (150 ml). After heating to room temperature, the compound is extracted with ether (3×200 ml). The combined organic phases are washed with a 2% aqueous solution of sodium hydroxide (200 ml and with water (3×200 ml), dried over magnesium sulphate and the solvents are removed in vacuo. The residue is recrystallised from hexane. The product is dried in vacuo to constant weight to yield 2-(3-trifluoromethylphenyl)-1-(4-methoxyphenyl)-ethanone, m.p. 94°-95°.

1. temperatureThe mixture is cooled to -5°
2. extractionthe compound is extracted with ether (3×200 ml)
3. washThe combined organic phases are washed with a 2% aqueous solution of sodium hydroxide (200 ml
4. dry with materialwith water (3×200 ml), dried over magnesium sulphate
5. customthe solvents are removed in vacuo
6. customThe residue is recrystallised from hexane
7. customThe product is dried in vacuo to constant weight