HRID620088

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID15107809

2-{[4-({2-[(Propan-2-yl)oxy]ethoxy}methyl)phenoxy]methyl}oxirane

C15H22O4

结构：COC(=O)C1=C(C)NC(C)=C(C(=O)OCCOc2ccc(OCC(C)(C)N)cc2)C1c1cccc([N+](=O)[O-])c1

HCID70393709

未命名化合物

PRODUCTS

生成物

结构：COC(=O)C1=C(C)NC(C)=C(C(=O)OCCOc2ccc(OCC(C)(C)NCC(O)COc3ccc(COCCOC(C)C)cc3)cc2)C1c1cccc([N+](=O)[O-])c1

HCID70393806

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

A solution of 4.6 g (8.5 mmol) of 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-pyridine-3,5-dicarboxylic acid 3-{2-[p-(2-amino-2-methylpropoxy)-phenoxy]-ethyl}-ester 5-methyl ester and 2.95 g (11 mmol) of 1-(2,3-epoxypropoxy)-4-[2-(isopropoxy)-ethoxymethyl]-benzene in 20 ml of isopropanol is heated under reflux for 6 hours while stirring. Working up and chromatographic purification analogously to Example 1 yield 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-pyridine-3,5-dicarboxylic acid 3-{{{2-{{p-{2-[[3-[4-(2-isopropoxyethoxymethyl)-phenoxy]-2-hydroxypropylamino]]-2-methylpropoxy}-phenoxy}}-ethyl}}}-ester 5-methyl ester in the form of a vitreous solid having the structure: ##STR38##

WORKUP

后处理

temperatureunder reflux for 6 hours
customWorking up and chromatographic purification analogously to Example 1

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8b053799ca474cf4ad134e2f7c29068d
来源数据集: uspto-grants-1989_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04818766
来源说明: uspto-grants-1989_04

反应 SMILES

[CH3:1][O:2][C:3]([C:5]1[CH:6]([C:31]2[CH:36]=[CH:35][CH:34]=[C:33]([N+:37]([O-:39])=[O:38])[CH:32]=2)[C:7]([C:13]([O:15][CH2:16][CH2:17][O:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][CH2:26][C:27]([NH2:30])([CH3:29])[CH3:28])=[CH:21][CH:20]=2)=[O:14])=[C:8]([CH3:12])[NH:9][C:10]=1[CH3:11])=[O:4].[O:40]1[CH2:58][CH:41]1[CH2:42][O:43][C:44]1[CH:49]=[CH:48][C:47]([CH2:50][O:51][CH2:52][CH2:53][O:54][CH:55]([CH3:57])[CH3:56])=[CH:46][CH:45]=1>C(O)(C)C>[CH3:1][O:2][C:3]([C:5]1[CH:6]([C:31]2[CH:36]=[CH:35][CH:34]=[C:33]([N+:37]([O-:39])=[O:38])[CH:32]=2)[C:7]([C:13]([O:15][CH2:16][CH2:17][O:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][CH2:26][C:27]([NH:30][CH2:58][CH:41]([OH:40])[CH2:42][O:43][C:44]3[CH:49]=[CH:48][C:47]([CH2:50][O:51][CH2:52][CH2:53][O:54][CH:55]([CH3:57])[CH3:56])=[CH:46][CH:45]=3)([CH3:29])[CH3:28])=[CH:21][CH:20]=2)=[O:14])=[C:8]([CH3:12])[NH:9][C:10]=1[CH3:11])=[O:4]