Sodium Hydroxide → 105950-89-8

HRID 620152Notes

Reaction equation

HRID 620152 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[NH:9][C:8](=O)[CH:7]=[CH:6][N:5]=1.[OH-].[Na+].P(Cl)(Cl)([Cl:15])=O>>[CH3:1][O:2][CH2:3][C:4]1[N:9]=[C:8]([Cl:15])[CH:7]=[CH:6][N:5]=1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 24813Phosphorus oxychlorideHCID 14306129HCID 14306129, compound

Product 1

HCID 14306130105950-89-8

Procedure

A mixture of 2-methoxymethyl-4-pyrimidone (1.73 g) and phosphorus oxychloride (20 ml) were heated together under reflux for 30 minutes. The mixture was stripped, ice/water added and the pH raised to 14 (NaOH). The solution was extracted with chloroform, the extracts dried (MgSO4) and stripped to give 2-methoxymethyl-4-chloropyrimidine (1.72 g) as an oil which was used without further purification.

Workup

  1. temperaturewere heated together
  2. temperatureunder reflux for 30 minutes
  3. extractionThe solution was extracted with chloroform
  4. dry with materialthe extracts dried (MgSO4)

Sources & evidence

ORD record
ord-2f1824f13241436eb43b8620e859e970
Source dataset
uspto-grants-1989_04
Patent number
US04820708

Reaction notes

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