反应详情

Piperidine (6.17 ml) in dichloromethane (40 ml) was added dropwise to a solution of 2-methoxymethyl-4-chloropyrimidine (4.71 g) in dichloromethane (40 ml). After standing overnight at room temperature the mixture was heated under reflux for 1 hour. After cooling the solution was washed with water, dried and stripped. The residue was chromatographed (silica gel, CHCl3) to give 2-methoxymethyl-4-piperidinopyrimidine (4.49 g) as an oil.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 1 hour
3. temperatureAfter cooling the solution
4. washwas washed with water
5. customdried
6. customThe residue was chromatographed (silica gel, CHCl3)