反应详情

7 g of sodium amide are added in small quantities to 27.11 g of 1-naphthylacetonitrile in 210 ml of anhydrous benzene. The mixture is heated for 2 hours to reflux and 22 g of 2-chlorodiethylaminoethane are added, the heating being continued to reflux for another two and a half hours. Then, the mixture is cooled and 200 ml of water are added. After decanting, the organic phase is extracted by HCl at 10%. The aqueous phase is washed in ether, neutralized with NaOH at 10%, then extracted with ether. After evaporation of the solvents, a red oil is obtained, which is distilled in vacuo.

1. temperatureThe mixture is heated for 2 hours
2. temperatureto reflux
3. temperatureto reflux for another two and a half hours
4. temperatureThen, the mixture is cooled
5. customAfter decanting
6. extractionthe organic phase is extracted by HCl at 10%
7. washThe aqueous phase is washed in ether
8. extractionextracted with ether
9. customAfter evaporation of the solvents
10. customa red oil is obtained
11. distillationwhich is distilled in vacuo