反应详情

8.2 g of sodium amide are added in small quantities on a solution of 33.4 g of 1-naphthyl acetonitrile in 450 ml of anhydrous ether. The mixture is heated for 2 hours to reflux, then 29.5 g of 2-piperidino-1-chloroethane are added, a heating to reflux is repeated for 5 hours. The mixture is then cooled, poured in water, and the organic phase is extracted 3 times with 600 ml of hydrochloric acid at 10%. The aqueous phase is washed with ether and neutralized with soda at 30%. The decanting oil is extracted, washed with sodium chloride-saturated water and dried over magnesium sulphate. After evaporation of the solvent, the resulting oil is distilled under reduced pressure (vane pump).

1. temperatureThe mixture is heated for 2 hours
2. temperatureto reflux
3. temperaturea heating to reflux
4. temperatureThe mixture is then cooled
5. extractionthe organic phase is extracted 3 times with 600 ml of hydrochloric acid at 10%
6. washThe aqueous phase is washed with ether and neutralized with soda at 30%
7. extractionThe decanting oil is extracted
8. washwashed with sodium chloride-saturated water
9. dry with materialdried over magnesium sulphate
10. customAfter evaporation of the solvent
11. distillationthe resulting oil is distilled under reduced pressure (vane pump)