HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 6-(2-amino-indan-5-yl)-4,5-dihydropyridazin-3(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Methyl 4-(2-amino-indan-5-yl)-4-oxobutyrate hydrochloride | HCID 23050575 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 6-(2-amino-indan-5-yl)-4,5-dihydropyridazin-3(2H)-one | HCID 14071499 | — |
Reaction Steps
8.5 g (0.17 mol) of 99% hydrazine hydrate are added to 10.0 g (0.035 mol) of methyl 4-(2-amino-indan-5-yl)-4-oxobutyrate hydrochloride in glacial acetic acid and the mixture is boiled for 30 minutes. The mixture is evaporated in vacuo, the residue is dissolved in water and the reaction product is precipitated by neutralisation with sodium hydroxide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04820705 |
| Source dataset | uspto-grants-1989_04 |
| ORD ID | ord-9c5bb891a85840e4aad887e05035831e |
| Source note | uspto-grants-1989_04 |