Hydrazine hydrate (1:1) → 6-(2-amino-indan-5-yl)-4,5-dihydropyridazin-3(2H)-one

HRID 620189Notes

Reaction equation

HRID 620189 reaction equation
O.[NH2:2][NH2:3].Cl.[NH2:5][CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:15](=O)[CH2:16][CH2:17][C:18]([O:20]C)=O)[CH:12]=2)[CH2:7]1>C(O)(=O)C>[NH2:5][CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:15]3[CH2:16][CH2:17][C:18](=[O:20])[NH:2][N:3]=3)[CH:12]=2)[CH2:7]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 23050575Methyl 4-(2-amino-indan-5-yl)-4-oxobutyrate hydrochloride

Product 1

HCID 140714996-(2-amino-indan-5-yl)-4,5-dihydropyridazin-3(2H)-one

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

8.5 g (0.17 mol) of 99% hydrazine hydrate are added to 10.0 g (0.035 mol) of methyl 4-(2-amino-indan-5-yl)-4-oxobutyrate hydrochloride in glacial acetic acid and the mixture is boiled for 30 minutes. The mixture is evaporated in vacuo, the residue is dissolved in water and the reaction product is precipitated by neutralisation with sodium hydroxide.

Workup

  1. customThe mixture is evaporated in vacuo
  2. dissolutionthe residue is dissolved in water
  3. customthe reaction product is precipitated by neutralisation with sodium hydroxide

Sources & evidence

ORD record
ord-9c5bb891a85840e4aad887e05035831e
Source dataset
uspto-grants-1989_04
Patent number
US04820705

Reaction notes

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