Pyruvic Acid → HCID 70377809, compound

HRID 620233Notes

Reaction equation

HRID 620233 reaction equation
C([NH:11][C@H:12]([C:14]([N:16]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][CH:23]=1)[CH2:17][C:18]([OH:20])=[O:19])=[O:15])[CH3:13])(OCC1C=CC=CC=1)=O.[C:29]([OH:34])(=[O:33])[C:30]([CH3:32])=[O:31]>C(O)C.[Pd]>[C:29]([OH:34])(=[O:33])[C:30]([CH3:32])=[O:31].[C:29]([CH:30]([NH:11][C@H:12]([C:14]([N:16]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][CH:23]=1)[CH2:17][C:18]([OH:20])=[O:19])=[O:15])[CH3:13])[CH3:32])([OH:34])=[O:33]

Participants

5

Reactant 2

HCID 1060Pyruvic AcidHCID 53939279HCID 53939279, compound

Product 1

HCID 70377809HCID 70377809, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of N-carbobenzoxy-L-alanyl-N-(4-methylbenzyl)-glycine (5.8 g, 15.1 mmol) and pyruvic acid (3.3 g, 37.8 mmol) in 200 ml absolute ethanol was added 10 palladium on carbon (0.5 g). The mixture was hydrogenated at 30 psi for 4 hours and filtered. Concentration of the volatiles in vacuo provided an oil product which was purified as in example 7D.

Workup

  1. filtrationfiltered
  2. customConcentration of the volatiles in vacuo provided an oil product which
  3. customwas purified as in example 7D

Sources & evidence

ORD record
ord-6084746f76e54d2285a76bc7a151c1c4
Source dataset
uspto-grants-1989_04
Patent number
US04820729

Reaction notes

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