Isobutyryl chloride → HCID 21246415, compound

HRID 620390Notes

Reaction equation

HRID 620390 reaction equation
Cl.[NH:2]=[C:3]1[CH:8]=[CH:7][N:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:5]=[CH:4]1.[C:15]([Cl:20])(=[O:19])[CH:16]([CH3:18])[CH3:17]>>[ClH:20].[C:15]([N:2]=[C:3]1[CH:8]=[CH:7][N:6]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:5]=[CH:4]1)(=[O:19])[CH:16]([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 62325Isobutyryl chlorideHCID 21246174HCID 21246174, compound

Product 1

HCID 21246415HCID 21246415, compoundYield 67%

Procedure

5.0 g (21.4 millimoles) of 1,4-dihydro-4-imino-1-phenylpyridazine hydrochloride in 20 ml of isobutyryl chloride were refluxed for 20 hours, while stirring. The mixture was cooled and then filtered under suction, and the residue was washed with acetone and recrystallized from ethanol/methyl tert.-butyl ether. 4.5 g (67% of theory) of 1,4-dihydro-4-isobutyrylimino-1-phenylpyridazine hydrochloride were isolated as colorless crystals of melting point 240°-242° C.

Workup

  1. temperatureThe mixture was cooled
  2. filtrationfiltered under suction
  3. washthe residue was washed with acetone
  4. customrecrystallized from ethanol/methyl tert.-butyl ether

Sources & evidence

ORD record
ord-c6f333de7875409986df9cef9293d901
Source dataset
uspto-grants-1989_04
Patent number
US04820821

Reaction notes

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