反应详情

500 mg of (-)-cis-chrysanthemic acid was dissolved in 10 ml of toluene, followed by adding 20 mg of azobisisobutyronitrile. Thereto was added dropwise a solution of bromine (19 mg) in carbon tetrachloride at 80° C. over a period of 10 minutes with stirring. After 15 minutes, the reaction mixture was subjected to a treatment similar to Example 1 to obtain 452 mg of chrysanthemic acid. The optical isomer ratio was as follows: (+)-cis, 3.3%; (-)-cis, 3.2%; (+)-trans, 47.0%; and (-)-trans, 46.5%.