反应详情

To a stirred solution of 4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)aniline (0.10 g, 0.31 mmol) in tetrahydrofuran (5 mL) was added 1-isopropyl-2-isothiocyanatobenzene (0.10 g, 0.56 mmol). The solution was heated to reflux for 24 hours The solvent was removed under reduced pressure, then triturated with methanol to generate a white solid which was filtered and air-dried to provide the title compound (0.070 g, 45%).

1. temperatureThe solution was heated
2. temperatureto reflux for 24 hours The solvent
3. customwas removed under reduced pressure
4. customtriturated with methanol
5. filtrationwas filtered
6. customair-dried